The complex Bum Bags life cycle of oncogenic human papillomavirus (HPV) initiates in undifferentiated basal epithelial keratinocytes where expression of the E6 and E7 oncogenes is restricted.Upon epithelial differentiation, E6/E7 transcription is increased through unknown mechanisms to drive cellular proliferation required to support virus replicat
Bradycardia and transient asystole are well-described sequelae of a myriad of neurologic insults, ranging from focal to generalized injuries.Increased vagal tone also predisposes many Bum Bags individuals, particularly adolescents, to transient neurally mediated bradyarrhythmia.However, prolonged periods of sinus arrest without junctional or ventri
Abstract Eicosanoids are major players in the pathogenesis of several common diseases, with either overproduction or imbalance (e.g.between thromboxanes and prostacyclins) often leading to worsening of disease symptoms.Both the total rate of eicosanoid production and the balance between eicosanoids with opposite effects are strongly dependent on di
The Bucha massacre raises the question of whether the Russian army predisposes its soldiers to unlawful violence against civilians.This article assumes that regardless of superior orders, perpetrators of violence must overcome the psychological barriers developed during socialisation.The psychological mechanism of "moral disengagement" allows Truck
The pulmonary microbiome has emerged as a significant factor in respiratory health and diseases.Despite the sterile conditions maintained during ex vivo lung perfusion (EVLP), the use of antibiotics in the perfuse liquid can lead to dynamic changes in the lung microbiome.Here, we present the design of a study that aims to investigate the hypothesis